The Distillery was founded in 1852 by William Mackenzie. When he died in 1865 his widow leased the distillery to James Fleming, a banker from Aberlour. Together with William Mackenzie’s son he founded Mackenzie and Company.

• 1863 Branch line opened to the distillery from Carron station on the Strathspey Railway, 1.25 miles long.
• 1884 Dailuaine is renovated and enlarged.
• 1891 Dailuaine-Glenlivet Distillery Ltd. was founded. In 1898, Dailuaine-Glenlivet and Talisker Distillery Ltd. are fused to Dailuaine-Talisker Distilleries Ltd.
• 1899 Charles C. Doig designs a new distillery with a pagoda like roof that becomes the standard design for Scottish distilleries.
• 1915 Thomas Mackenzie died and the company was sold to John Dewar & Sons, John Walker & Sons and James Buchanan & Co. one year later.
• 1917 a fire destroyed the pagoda-roof. The distillery had to close, reopened three years later and was bought by Distillers Company Limited (DCL) in 1925.
• 1960 the Distillery is completely renovated and is enlarged from four to six stills. Since 1983 the malt is no longer produced inhouse.
• 1939 New 0-4-0ST loco purchased from the Caledonia Works of Andrew Barclay Sons & Co. Ltd., Kilmarnock (AB2073/1939) to work the branch to the mainline at Carron. Loco named after the distillery, DAILUAINE.
• 1987 Dailuaine was taken over by United Distillers (UD)